The association of human leucocyte antigen (HLA) alleles with COVID-19 severity: A systematic review and meta-analysisReview Published on 2023-01-012023-07-10 Journal: Reviews in Medical Virology [Category] COVID19(2023년), [키워드] COVID-19 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1. [DOI] 10.1002/rmv.2378 PMC 바로가기 [Article Type] Review
Genomic variants-driven drug repurposing for tuberculosis by utilizing the established bioinformatic-based approachShort communication Published on 2022-12-012022-10-05 Journal: Biochemistry and Biophysics Reports [Category] 신약개발, [키워드] annotations applied approach bioinformatics biological process CCR5 CD44 cellular component contribute CXCR4 demonstrated deregulation disease disease-associated drug Drug discovery Drug repurposing drug target evaluated Evidence facilitate functional functional annotation Genes genomic genomic variant genomic variants GWAS HLA-B identify implementation in-silico indication involved KEGG Missense mutation molecular overlapped Pathogenesis Pathway analysis provided risk SELP suggested target Treatment Tuberculosis variant [DOI] 10.1016/j.bbrep.2022.101334 [Article Type] Short communication
Association between HLA-C alleles and COVID-19 severity in a pilot study with a Spanish Mediterranean Caucasian cohort스페인 지중해 백인 코호트를 대상으로 한 파일럿 연구에서 HLA-C 대립형질과 COVID-19 심각성 사이의 연관성Article Published on 2022-08-122022-09-11 Journal: PLoS ONE [Category] SARS, 유전자 메커니즘, [키워드] age allele analyzed antiviral response association Asymptomatic cause Cell cell surface class Clinical characteristics clinical presentation Clinical presentations Cohort Comorbidity contrary COVID-19 COVID-19 severity Critical described determine disease epitope Epitopes expressed Factor fatal disease Gender groups HLA HLA allele HLA alleles HLA class I HLA-A HLA-B HLA-B allele HLA-B alleles HLA-C HLA-C allele HLA-C alleles HLA-C1 Host hyperinflammatory state immune response individual Infection involved KIR gene male management mechanism Mild mild infection no significant difference no significant differences outcomes pandemic peptide peptides pilot study recruited SARS-CoV-2 protein SARS-CoV-2 proteins significant difference significant differences small sample size Spain Spanish T cells β2-microglobulin [DOI] 10.1371/journal.pone.0272867 PMC 바로가기 [Article Type] Article
Allelic imbalance of HLA-B expression in human lung cells infected with coronavirus and other respiratory viruses코로나바이러스 및 기타 호흡기 바이러스에 감염된 인간 폐 세포에서 HLA-B 발현의 대립형질 불균형Article Published on 2022-08-012022-09-11 Journal: European Journal of Human Genetics [Category] SARS, 변종, 유전자 메커니즘, [키워드] accompanied allelic analysis Analysis Antigen Antiviral association cells characterized contribute coronavirus cytokine Diseases epithelial cells experimental evidence expression genotypes heterozygous HLA HLA allele HLA alleles HLA-B human lung human lung cell human lung epithelial cells IFNβ in silico independent data set infected with SARS-CoV-2 less leucocyte loci lung cell lung cells other respiratory virus overexpression performed predicted respiratory viral infection respiratory viral infections respiratory virus RNA-seq data SARS-CoV-2 tissues viral infectious disease viral infectious diseases with COVID-19 [DOI] 10.1038/s41431-022-01070-5 PMC 바로가기 [Article Type] Article
Genetic polymorphisms associated with susceptibility to COVID-19 disease and severity: A systematic review and meta-analysisCOVID-19 질병 및 중증도에 대한 감수성과 관련된 유전적 다형성: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-07-062022-09-11 Journal: PLoS ONE [Category] 변종, [키워드] 95% CI ACE1 advanced age allele alleles analyzed ApoE article association C allele calculated candidate gene CCR5 clinical symptom Clinical symptoms Comorbidities contribute COVID-19 COVID-19 disease COVID-19 infection COVID-19 pathogenesis COVID-19 severity disease eligible fixed form forms Genetic polymorphism genetic polymorphisms Genetic variant genetic variants GWAS HLA HLA-A HLA-B HLA-C identify investigated involved loci Meta-analysis polymorphism Polymorphisms presence of comorbidity random Repository risk searched severe forms of COVID-19 severity of COVID-19 significantly Stata software suggested susceptibility systematic review the disease TMPRSS2 Variation [DOI] 10.1371/journal.pone.0270627 PMC 바로가기 [Article Type] Meta-Analysis
Monocytic-Myeloid Derived Suppressor Cells Suppress T-Cell Responses in Recovered SARS CoV2-Infected Individuals단핵구 골수 유래 억제 세포는 회복된 SARS CoV2에 감염된 개인의 T 세포 반응을 억제합니다Article Published on 2022-06-242022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, 치료법, 치료제, [키워드] adaptive immune responses Antigen arginase caused CD11b CD14 CD33 CD57 Cell characterized clinical recovery coronavirus disease Coronavirus disease 2019 correlated COVID-19 CX3CR1 CXCL1 CXCL2 cytokine production Cytokine storm Cytokines depleting dominant downregulated DQA1 DQB1 effector memory expansion Frequency function functional functions Gene Expression HLA-B HLA-DQA1 HLA-DQB1 HLA-DR Hyperinflammatory Hyperinflammatory response IL-6 IL1β immune immune activation immune responses individual individuals infected individual Infection membrane monocytic-myeloid derived suppressor cells mononuclear cell NLRP3 nucleocapsid pathway Pathway analysis Pathways PBMC PD1 peptide peptide pool peptide pools Peripheral blood Peripheral blood mononuclear cells plasma quantity recall recovered regulate remained response RNA-Seq ROS SARS Coronavirus SARS coronavirus 2 SARS CoV2 infection shown spike glycoprotein subset suppress suppresse suppressed suppressor T cell T cell response T cell responses T-cell T-cell responses target TGFβ transcriptional transcriptomic transcriptomic (RNA-Seq). Vaccine viral infection virus [DOI] 10.3389/fimmu.2022.894543 PMC 바로가기 [Article Type] Article
The mutational landscape of SARS-CoV-2 variants diversifies T cell targets in an HLA-supertype-dependent mannerSARS-CoV-2 변이체의 돌연변이 환경은 HLA 수퍼타입 의존 방식으로 T 세포 표적을 다양화합니다Article Published on 2022-02-162022-09-11 Journal: Cell Systems [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] analyzed CD8 country COVID-19 delta variant dominant driven by epitope Epitopes expressing HLA HLA-B HLA-B allele HLA-B alleles Immunity immunodominant individual mass vaccination mutants Mutation pandemic peptide population level predicted prevalent proline proteome residue RNA SARS-CoV-2 SARS-CoV-2 genome assemblies SARS-CoV-2 variant supertype T cell T cell epitope T cell epitopes target vaccination variant Variant. variants [DOI] 10.1016/j.cels.2021.09.013 PMC 바로가기 [Article Type] Article
HLA-C*04:01 Affects HLA Class I Heterozygosity and Predicted Affinity to SARS-CoV-2 Peptides, and in Combination With Age and Sex of Armenian Patients Contributes to COVID-19 SeverityHLA-C*04:01 SARS-CoV-2 펩티드에 대한 HLA 클래스 I 이형접합 및 예측된 친화도에 영향을 미치고 아르메니아 환자의 연령 및 성별과 함께 COVID-19 심각도에 기여Immunology Published on 2022-02-032022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] 95% CI advanced age affinity affinity to SARS-CoV-2 age Antigen Armenian population Armenians association Asymptomatic Asymptomatic COVID-19 AUC carriers change class contribute contributed Control COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 severity COVID-19 susceptibility decrease deficiency demographic variable disease severity disease symptom distribution dose-dependent manner Effect examined Frequency Genotype Health heterozygosity HLA HLA allele HLA classical genes HLA-B HLA-B*51:01 HLA-C HLA-C*04:01 HLA-C*04:01 allele HLA-I heterozygosity homozygous Hospitalization host immunity incidence Infection Interaction leukocyte loci Male sex outcome Patient patients peptide Personalized medicine predicted Prevalence Protective provided recognize risk SARS-CoV-2 SARS-CoV-2 coronavirus SARS-CoV-2 peptides severe COVID-19 severity severity risk modelling Sex significant increase significantly subgroup the disease the SARS-CoV-2 translated Variability [DOI] 10.3389/fimmu.2022.769900 PMC 바로가기 [Article Type] Immunology
T-CoV: a comprehensive portal of HLA-peptide interactions affected by SARS-CoV-2 mutationsT-CoV: SARS-CoV-2 돌연변이의 영향을 받는 HLA-펩티드 상호작용의 종합 포털AcademicSubjects/SCI00010 Published on 2022-01-072022-09-10 Journal: Nucleic Acids Research [Category] SARS, 변종, [키워드] (alpha Affect affected affinity alleles Alpha Alter alteration Atla atlas binding affinities CD4 T-cell CD8 clinician COVID-19 Delta dependent on Diversity Epitopes evade example Genotype help highlight HLA HLA allele HLA alleles HLA class I HLA molecule HLA molecules HLA-B In silico methods individual Infection Interaction peptide peptides portal predict researcher responses SARS-CoV-2 mutation SARS-CoV-2 mutations severity susceptibility T cell T cell epitopes T-cell T-cell responses variant variants variants of SARS-CoV-2 viral peptide viral peptides virus virus variant were assessed Wuhan [DOI] 10.1093/nar/gkab701 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
Bioinformatic analyses suggest augmented interleukin-17 signaling as the mechanism of COVID-19-associated herpes zoster생물 정보학 분석은 COVID-19 관련 대상 포진의 메커니즘으로 증강된 인터루킨-17 신호 전달을 제안합니다Article Published on 2021-12-012022-09-11 Journal: Environmental science and pollution research inter [Category] 두창, 수두, 유전자 메커니즘, 홍역, [키워드] analysis ApoE ARSA Bioinformatic blistering CCR2 CCR5 cell differentiation correlation COVID-19 CRP CXCL13 cytokine cytokine receptor distribution dorsal root ganglia DRB1 EGFR ESR1 Genetic GP2 Herpe herpes zoster herpetic neuralgia HLA-A HLA-B HLA-DRB1 IL-17 IL10 IL17A IL5 IL6 IL7 Increasing indicated Interaction interleukin-17 involved Jak-STAT mechanism pathophysiological mechanism raise raised Rash receptor resulting risk SARS-CoV-2 Signaling STAT STAT3 subset suggested TECTA Th17 THBS1 TNF varicella Varicella zoster virus Varicella zoster virus. virus Zoster [DOI] 10.1007/s11356-021-15567-x PMC 바로가기 [Article Type] Article